Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment
نویسندگان
چکیده
Cancer cells generate reactive oxygen species (ROS) resulting from mitochondrial dysfunction, stimulation of oncogenes, abnormal metabolism, and aggravated inflammatory activities. Available evidence also suggests that cancer cells depend on intrinsic ROS level for proliferation and survival. Both physiological and pathophysiological roles have been ascribed to ROS which cause lipid peroxidation. In spite of their injurious effects, the ROS and the resulting lipid peroxidation products could be beneficial in cancer treatment. This review presents research findings suggesting that ROS and the resulting lipid peroxidation products could be utilized to inhibit cancer growth or induce cancer cell death. It also underscores the potential of lipid peroxidation products to potentiate the antitumor effect of other anticancer agents. The review also highlights evidence demonstrating other potential applications of lipid peroxidation products in cancer treatment. These include the prospect of lipid peroxidation products as a diagnostic tool to predict the chances of cancer recurrence, to monitor treatment progress or how well cancer patients respond to therapy. Further and detailed research is required on how best to successfully, effectively, and selectively target cancer cells in humans using lipid peroxidation products. This may prove to be an important strategy to complement current treatment regimens for cancer patients.
منابع مشابه
The study of antioxidant potential of Morus alba L. leaves extract
Background & Aim: Applications of synthetic antioxidant in food have side effects. In present study, the antioxidant potential of Morus alba leaves, as natural antioxidant, was screened with cupric ion reducing assay (CUPRAC assay) and inhibition of lipid peroxidation. The aim of this study was to determine the total antioxidant activity of Morus alba leaves. Martial & Method...
متن کاملThe study of antioxidant potential of Morus alba L. leaves extract
Background & Aim: Applications of synthetic antioxidant in food have side effects. In present study, the antioxidant potential of Morus alba leaves, as natural antioxidant, was screened with cupric ion reducing assay (CUPRAC assay) and inhibition of lipid peroxidation. The aim of this study was to determine the total antioxidant activity of Morus alba leaves. Martial & Method...
متن کاملEffects of Pongamia pinnata on Lipid Peroxidation Products and Antioxidants in Hyperammonemic Rats: with Reference to Circadian Variations
Effects of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-(AC)-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata (PPEt), and PPEt-treated. The...
متن کاملAntinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation
Background and Objective: Due to the presence of some evidence for anti-diabetic and antioxidant activity of Tribulus terrestris (TT), this study was designed to investigate the anti-nociceptive effect of TT in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. Materials and Methods: Rats were divided into control, TT-treated control, diabetic, sodium salicylate (SS)...
متن کاملAntioxidative Effects of Nano-curcumin on Liver Mitochondria Function in Paraquat-induced Oxidative Stress
Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction. Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013